TRITERPENOID AND STEROL COMPOUNDS ISOLATED FROM ANODENDRON PANICULATUM (ROXB.) A. DC.

Abstract

This phytochemical study on the aerial parts of Anodendron paniculatum led to the isolation of three triterpenes, namely ursolic acid (1), esculentic acid (2), cycloartenol (3), and one sterol: desmosterol (4). Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds against the growth of human cancer cell lines was evaluated using the sulforhodamine B bioassay. Compounds 1 exhibited a moderate cytotoxicity against the LU–1 and MKN–7 cell lines with IC₅₀ values of 44.37 ± 5.40 and 30.89 ± 3.60 μg/mL, respectively. Meanwhile, compound 4 possessed moderate cytotoxic effects toward the LU–1, KB, Hep–G2, MKN–7 and SW–480 cell lines with IC₅₀ values ranging from 28.11 ± 1.95 to 41.41 ± 2.31 μg/mL.