Chemical constituents and cytotoxicity of Aspidistra letreae
Vol. 129 No. 1B (2020), Original Article
Vol. 129 No. 1B (2020)

Chemical constituents and cytotoxicity of Aspidistra letreae

Original Article
https://doi.org/10.26459/hueuni-jns.v129i1B.5656
Published 2020-06-22
Duc Viet Ho
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
https://orcid.org/0000-0002-7442-3925
Hanh Nhu Thi Hoang
University of Agriculture and Forestry, Hue University, 102 Phung Hung St., Hue, Vietnam
Khue Minh Vo
University of Education, Hue University, 34 Le Loi St., Hue, Vietnam
Anh Tuan Le
Quang Tri Center of Science and Technology, Mientrung Inst. for Scientific Research, VAST, Dien Bien Phu St., Quang Tri, Vietnam
Hoai Thi Nguyen
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
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Keywords

NMR
bioactivity
anticancer
cytotoxicity
extraction
isolation
structure elucidation

How to Cite

1.
Ho DV, Hoang HNT, Vo KM, Le AT, Nguyen HT. Chemical constituents and cytotoxicity of Aspidistra letreae. hueuni-jns [Internet]. 2020Jun.22 [cited 2024Nov.23];129(1B):31-9. Available from: http://222.255.146.83/index.php/hujos-ns/article/view/5656
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Abstract

A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2H-chromen-2-one (1), α-tocopherol (2), (E)-phytol (3), asparenydiol (4) and (25S)-spirost-1β,3α,5β-triol (5). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (4) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25S)-spirost-1β,3α,5β-triol (5) as a pure compound. The methanol extract from the whole plants of Aspidistra letreae exhibits moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.

https://doi.org/10.26459/hueuni-jns.v129i1B.5656
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