In vitro bioactivities of Codonopsis javanica root extract from Kon Tum province, Vietnam
Vol. 131 No. 1B (2022), Original Article
Vol. 131 No. 1B (2022)

In vitro bioactivities of Codonopsis javanica root extract from Kon Tum province, Vietnam

Original Article
https://doi.org/10.26459/hueunijns.v131i1B.6419
Published 2022-06-30
Pham Thi Thu Ha
NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh St., District 4, Ho Chi Minh City, Vietnam
Tran Kien Cuong
NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh St., District 4, Ho Chi Minh City, Vietnam
Nguyen Thi Thu Nha
NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh St., District 4, Ho Chi Minh City, Vietnam
Nguyen Phan Hoang Lan
Biochemistry and Molecular Biology Department, Gettysburg College, 300 North Washington St., Gettysburg, PA, USA
Nguyen Huu Thuan Anh
NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh St., District 4, Ho Chi Minh City, Vietnam
Bach Long Giang
NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh St., District 4, Ho Chi Minh City, Vietnam
Than Thi Minh Phuong
Center for Research, Application and Service of Science and Technology, 16A Ngo Quyen St., Thong Nhat District, Kon Tum Province, Vietnam
Chu Dinh Lieu
Center for Research, Application and Service of Science and Technology, 16A Ngo Quyen St., Thong Nhat District, Kon Tum Province, Vietnam
Van Thanh Le
Center for Research, Application and Service of Science and Technology, 16A Ngo Quyen St., Thong Nhat District, Kon Tum Province, Vietnam
Nguyen Thanh Luan*
Department of Science and Technology and International Affairs, HUTECH University, 475A Dien Bien Phu St., Binh Thanh District, Ho Chi Minh City, Vietnam
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Keywords

kháng khuẩn
kháng ung thư
kháng oxy hóa
các hợp chất có hoạt tính sinh học
Đảng Sâm Codonopsis javanica antibacterial
anticancer
antioxidant
bioactive compounds
Dangshen Codonopsis javanica

How to Cite

1.
Pham Thi HH, Tran KC, Nguyen TTN, Hoang Nguyen LP, Nguyen Huu TA, Bach LG, Than TMP, Chu DL, Le VT, Nguyen TL. In vitro bioactivities of Codonopsis javanica root extract from Kon Tum province, Vietnam. hueuni-jns [Internet]. 2022Jun.30 [cited 2024Nov.14];131(1B):11-8. Available from: http://222.255.146.83/index.php/hujos-ns/article/view/6419
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Abstract

Dangshen Codonopsis javanica exhibits invaluable medicinal properties in herbal remedies; however, there has currently not been much specific analysis of the phytochemicals and bioactivities of this plant. The root ethanol extract of C. javanica contains substances such as saponins, phenolic acids, terpenoids, and alkaloids. It displays an antibacterial effect against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus with the IC50 values of 150, 100, 150, and 90 μg/mL, respectively. The antioxidant capacity of the root extract was also observed with an IC50 value of 46.8 ± 6.8 μg/mL. Furthermore, the extract exhibits activity on human cancer cell lines HepG2 (IC50 = 83.6 ± 2.7 μg/mL) and MCF-7 (IC50 = 95.3 ± 2.3 μg/mL). Hence, this study provides the basic data for further research on the bioactivities of natural compounds of Dangshen C. javanica for the first time.

https://doi.org/10.26459/hueunijns.v131i1B.6419
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