Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems
Vol. 131 No. 1A (2022), Original Article
Vol. 131 No. 1A (2022)

Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems

Original Article
https://doi.org/10.26459/hueunijns.v131i1A.6637
Published 2022-03-31
Le Lam Son
University of Sciences, Hue University, 77 Nguyen Hue St., Hue, Vietnam
Le Thuy Trang
University of Sciences, Hue University, 77 Nguyen Hue St., Hue, Vietnam
Tran Thi Van Thi
University of Sciences, Hue University, 77 Nguyen Hue St., Hue, Vietnam
Nguyen Vinh Phu
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
Nguyen Quang Man
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
Le Trung Hieu*
University of Sciences, Hue University, 77 Nguyen Hue St., Hue, Vietnam
PDF (Vietnamese)

Keywords

drug delivery system
pH-sensitive
hydrogel hệ thống phân phối thuốc
glucomannan-poly(acrylic acid)
hydrogel nhạy pH

How to Cite

1.
Le LS, Le TT, Tran TVT, Nguyen VP, Nguyen QM, Le TH. Synthesis and characterization of pH-sensitive glucomannan-poly(acrylic acid) hydrogels for 5-aminosalicylic acid controlled delivery systems. hueuni-jns [Internet]. 2022Mar.31 [cited 2024Nov.23];131(1A):65-74. Available from: http://222.255.146.83/index.php/hujos-ns/article/view/6637
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Abstract

In this study, glucomannan-poly(acrylic acid) hydrogels were synthesized under different conditions. The hydrogels consist of glucomannan and acrylic acid and are crosslinked by N,N-methylene-bis-(acrylamide). The structure and morphology of the hydrogels were investigated by using Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM). The swelling ratio, biodegradation and pH-sensitive properties, relationship between hydrogel swelling rate and 5-ASA adsorption-desorption capacity, influence of medium pH on 5-ASA desorption, and 5-ASA adsorption kinetics were studied. The swelling ratio of the synthesized hydrogel samples is 16.70–56.21 times. This ratio is low in the pH 1.0 media and increases significantly in the pH 7,4 media. The hydrogels are biodegradable in the presence of cellulase (400 U·mg–1) in a pH 7.4 phosphate buffer at 37 °C (69.8% after ten days; the cellulase concentration 1.5 g·L­–1). The hydrogels exhibit high adsorption and desorption capacities for 5-ASA. The adsorption kinetics follows the pseudo-first-order model. These hydrogels can be applied to smart drug delivery systems.

https://doi.org/10.26459/hueunijns.v131i1A.6637
PDF (Vietnamese)

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