Keywords
tổng hợp bất đối xứng
oxazoline
Ru(II)-pheox Ru(II)-dialkyl-pheox
asymmetric synthesis
oxazoline derivatives
Ru(II)-pheox catalyst
How to Cite
Abstract
The development of new pharmaceutical products containing pure enantiomers is a recent direction in the world’s pharmaceutical industry. Asymmetric catalysts play an essential role in the synthesis of pure enantiomers. The Ru(II)-pheox catalyst has been reported to be effective for the asymmetric reactions producing pure enantiomers. In this study, an asymmetric synthesis of Ru(II)-dialkyl-pheox derivatives is proposed. The process consists of the asymmetric synthesis of oxazoline derivatives from precursors and the complexation between ruthenium and oxazoline ligands. With this procedure, four Ru(II)-dialkyl-pheox derivatives were successfully synthesized with a high yield (>60%).
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