Flavanoids and diarylheptanoids from Conamomum rubidum Lamxay & N.S.Lý
Vol. 133 No. 1A (2024), Original Article
Vol. 133 No. 1A (2024)

Flavanoids and diarylheptanoids from Conamomum rubidum Lamxay & N.S.Lý

Original Article
https://doi.org/10.26459/hueunijns.v133i1A.7264
Published 2024-03-29
Hoang Thi Nhu Hanh
University of Agriculture and Forestry, Hue University, 102 Phung Hung St., Hue, Vietnam
Nguyen Thi Ngoc Kieu
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
Ho Thi Hoai Nhi
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
Ho Viet Duc*
University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
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How to Cite

1.
Hoàng Thị Như H, Nguyễn Thị Ngọc K, Hồ Thị Hoài N, Hồ Đức V. Flavanoids and diarylheptanoids from Conamomum rubidum Lamxay & N.S.Lý. hueuni-jns [Internet]. 2024Mar.29 [cited 2024Nov.23];133(1A):15-22. Available from: http://222.255.146.83/index.php/hujos-ns/article/view/7264
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Abstract

Five compounds included two dihydrochalcones, 2’,6’-dihydroxy-4’-methoxydihydrochalcone (1), dihydroflavokawin B (2), one flavanone, pinocembrin (3) and two diarylheptanoids, dihydroyashabushiketol (4), 5-methoxy-1,7-diphenyl-3-heptanone (5) were isolated for the first time from the whole plants of Conamomum rubidum. The structure of isolates were determined by a combination of spectroscopic analyses as well as by comparison with the reported spectroscopic data. Biological evaluations revealed that compounds 2, 4, and 5 inhibited NO production in RAW 264.7 cells with IC50 values ranging from 58.16 ± 3.02 to 81.95 ± 2.87 µM. Compound 1 exhibited moderate cytotoxicity against the SK-LU-1 cells with IC50 value of 58.45 ± 2.26 µM.

https://doi.org/10.26459/hueunijns.v133i1A.7264
PDF (Vietnamese)

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