Keywords
Ethambutol
V/UiO-66
electrochemical analysis Ethambutol
V/UiO-66
Phân tích điện hóa
V/UiO-66
electrochemical analysis Ethambutol
V/UiO-66
Phân tích điện hóa
How to Cite
1.
Phạm THT, Nguyễn QM, Đoàn KNH, Lê LS. A V/UiO-66 metal-organic framework-modified glassy carbon electrode for electrochemical determination of ethambutol. hueuni-jns [Internet]. 2026Sep.23 [cited 2026Oct.28];135(1C):81-9. Available from: http://222.255.146.83/index.php/hujos-ns/article/view/8444
Abstract
A sensitive electrochemical sensor based on a vanadium-incorporated UiO-66 metal-organic framework-modified glassy carbon electrode (V/UiO-66/GCE) was developed for determining ethambutol in pharmaceutical formulations. The V/UiO-66 material was synthesised via a hydrothermal method and comprehensively characterised with X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy with elemental mapping. Under optimal conditions, the V/UiO-66/GCE exhibited a well-defined oxidation peak, enabling the quantification of ethambutol with a limit of detection of 0.81 μmol.L⁻¹. The proposed method was successfully applied to the analysis of commercial tablets, yielding an acceptable recovery of 95.50%. These results indicate that the V/UiO-66/GCE provides a simple, reliable, and efficient electrochemical approach for the determination of ethambutol.
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