The Synthesis of hybrid compounds of 24-nor-lupane triterpene and amino acids via C-28 amide linkage
Vol. 132 No. 1B (2023), Original Article
Vol. 132 No. 1B (2023)

The Synthesis of hybrid compounds of 24-nor-lupane triterpene and amino acids via C-28 amide linkage

Original Article
https://doi.org/10.26459/hueunijns.v132i1B.6810
Published 2023-06-30
Nguyen Hoang Sa*
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay, Hanoi, Vietnam
Nguyen Ha Thanh
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay, Hanoi, Vietnam
Tran Van Loc
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay, Hanoi, Vietnam
Le Nhat Thuy Giang
Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet St., Cau Giay, Hanoi, Vietnam
Le Cong Hoan
University of Khanh Hoa, 1 Nguyen Chanh St., Nha Trang, Khanh Hoa, Vietnam
Ngo Thi Uyen Tuyen
University of Khanh Hoa, 1 Nguyen Chanh St., Nha Trang, Khanh Hoa, Vietnam
Dang Thi Tuyet Anh
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet St., Cau Giay, Hanoi, Vietnam
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Keywords

24-nor-3-oxo-20(29)-lupen-28-oic acid, L-leucine, amide, hybrid compounds

How to Cite

1.
Nguyen HS, Nguyen HT, Tran VL, Le NTG, Le CH, Ngo TUT, Dang TTA. The Synthesis of hybrid compounds of 24-nor-lupane triterpene and amino acids via C-28 amide linkage. hueuni-jns [Internet]. 2023Jun.30 [cited 2024Nov.15];132(1B):43-7. Available from: http://222.255.146.83/index.php/hujos-ns/article/view/6810
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Abstract

Betulinic acid derivatives exhibit different biological activity against diversified targets, such as anticarcinogenic activity in experimental animals, anti-HIV, antihyperglycemia, and anti-inflammatory in humans. In this work, we investigated the synthetic procedure of 24-nor-3-oxo-20(29)-lupen-28-oic acid (1) derivatives. Starting from compound 1 and L-leucine methyl ester, we proceeded with amidification, reduction, and hydrolysis under basic conditions. Finally, three hybrid compounds were successfully synthesised and elucidated with spectral means.

https://doi.org/10.26459/hueunijns.v132i1B.6810
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