CYTOTOXIC CONSTITUENTS FROM AERIAL PARTS OF HELICTERES HIRSUTACOLLECTED IN BINH PHUOC PROVINCE

Tóm tắt

Helicteres hirsuta plant is a member of Helicteres genus of the plant family Sterculiaceae and widely found in countries of South Asia such as Vietnam, Lao, Thailand etc. In recent years, it is known as a new folk medicine protecting and securing people against human lung carcinoma, hormone - dependent human prostate carcinoma and human liver. In this paper, from aerial parts of Helicteres hirsuta plant, collected in Binhphuoc province (October, 2016) three pure compounds 1-3 were isolated and structurally elucidated, such as b-stigmasterol (1), protosta-17(20), 24-dien-3b-ol (2) and icosanoic acid (3). Among them, compound 2 has a remarkable cytotoxic activity against SK-LU-1, Hep-G2, and Hela cell lines with IC₅₀ values from 32.86 to 77.31 mg/mL, meanwhile compound 3 shows a moderable cytotoxic activity against SK-Mel-2, AGS, SK-LU-1, Hep-G2, and Hela cell lines with IC₅₀ values from 59.02 to 80.87 mg/mL.