Iridoid glycosides from Gomphandra tonkinensis Gagnep.
Vol. 134 No. 1C (2025), Original Article
Vol. 134 No. 1C (2025)

Iridoid glycosides from Gomphandra tonkinensis Gagnep.

Original Article
https://doi.org/10.26459/hueunijns.v134i1C.7758
Published 2025-06-17
Tran Phan Thi Diem
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 321 Huynh Thuc Khang, Hue City
Ha Tran Phuong
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 321 Huynh Thuc Khang, Hue City
Tam Vu Thi Thanh
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, 321 Huynh Thuc Khang, Hue, Thua Thien Hue, Vietnam
Dat Ton That Huu
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, 321 Huynh Thuc Khang, Hue, Thua Thien Hue, Vietnam
Hieu Le Trung
University of Sciences, Hue University, 77 Nguyen Hue St., Hue, Vietnam
Le Canh Viet Cuong*
Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, 321 Huynh Thuc Khang, Hue, Thua Thien Hue, Vietnam
PDF (Vietnamese)

How to Cite

1.
Phan Thị Diễm T, Trần Phương H, Vũ Thị Thanh T, Tôn Thất Hữu Đạt, Lê Trung H, Cường LCV. Iridoid glycosides from Gomphandra tonkinensis Gagnep. hueuni-jns [Internet]. 2025Jun.17 [cited 2025Oct.10];134(1C):125-33. Available from: http://222.255.146.83/index.php/hujos-ns/article/view/7758
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Abstract

Four iridoid glycosides, namely sweroside (1), loganin (2), triplostoside A (3), and gomphandranoside C (4), were isolated from the roots of Gomphandra tonkinensis Gagnep. collected in Thua Thien Hue. The chemical structures of isolated compounds were determined based on 1D-NMR and 2D-NMR spectral data and compared with previously published information. Compound 1 exhibits the ability to inhibit diabetes-related enzymes (α-amylase and α-glucosidase) with IC50 values ​​of 331.1 ± 8.6 µg/mL and 344.2 ± 6.0 µg/mL, respectively. Compound 2 has α-glucosidase inhibitory activity with an IC50 value of 270.9 ± 9.7 µg/mL. Triplostoside A (3) is isolated from the genus Gomphandra for the first time.

https://doi.org/10.26459/hueunijns.v134i1C.7758
PDF (Vietnamese)

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