Optimizing the extraction process of paracetamol and chlorpheniramine maleate mixed in herb products
Vol. 134 No. 1A (2025), Original Article
Vol. 134 No. 1A (2025)

Optimizing the extraction process of paracetamol and chlorpheniramine maleate mixed in herb products

Original Article
https://doi.org/10.26459/hueunijns.v134i1A.7618
Published 2025-03-19
Thi Cam Minh Dao
Faculty of Pharmacy, University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Viet Nam
Hai Phong Nguyen
Faculty of Chemistry, University of Sciences, Hue University, 77 Nguyen Hue St., Hue, Vietnam
Dang Thuy Anh Nguyen
Faculty of Pharmacy, University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Viet Nam
Huynh Van Chung*
Faculty of Pharmacy, Buon Ma Thuot Medical University, 298 Ha Huy Tap St., Đak Lak, Viet Nam
PDF (Vietnamese)

How to Cite

1.
Đào TCM, Nguyễn HP, Nguyễn Đăng TA, Huỳnh VC. Optimizing the extraction process of paracetamol and chlorpheniramine maleate mixed in herb products. hueuni-jns [Internet]. 2025Mar.19 [cited 2025Apr.26];134(1A):113-21. Available from: http://222.255.146.83/index.php/hujos-ns/article/view/7618
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Abstract

In this study, we optimised the extraction procedure for paracetamol and chlorpheniramine maleate by using the response surface method with the Box-Behnken model. The influencing factors are ethanol concentration, extraction time, and liquid-to-solid ratio. The optimal extraction conditions for paracetamol and chlorpheniramine maleate mixed in medicinal herbs are as follows: ethanol concentration 96%; extraction time 14.04 minutes; liquid/ solid ratio 51.41 mL/g. Under these optimal conditions, the extraction efficiency of paracetamol and chlorpheniramine maleate is 98.10 and 95.64%, respectively. The optimization results were experimentally verified, showing a close agreement with the predicted model.

https://doi.org/10.26459/hueunijns.v134i1A.7618
PDF (Vietnamese)

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